Malignant epithelial cells isolated from PTC and ATC [7] produced in vitro IL-4 and IL-10, which increased the expression of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xL), cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (cFLIP), and Phosphoprotein enriched in diabetes/Astrocytic phosphoprotein (PED/PEA-15) in TC cells [54,55]. This evidence concerns the gene PEA15 and diabetes mellitus.