TNF and breast cancer: By contrast, our classification was strongly associated with prognostic immunity-related signatures reported in ER-negative BC (IR signature, LCK signature, and Immune 28-kinase), and with signatures/metagenes reflecting the activation and/or enrichment of different types of immune cells/responses, such as the activation score of IFNα, IFNγ, and TNFα pathways, the cytolytic activity score, and Bindea’s signatures for immune cells involved in cytotoxic immune antitumor response.