PRF1 and neoplasm: The correlation of our 13-gene classifier with immune features was clearly demonstrated, because ontology analysis showed that the genes overexpressed in “low-risk” samples are involved in both canonical T-cell/B-cell receptors signaling pathways (e.g., Interferon-γ, perforins or granzymes genes) and in a RAS/RAC-trafficking modulation pathway potentially involved in the induction of lymphocyte-mediated tumor cells apoptosis [53].