EPHB4 and breast cancer: Five genes of the signature had expression associated with shorter DFS in univariate analysis: ALK, which codes for Anaplastic lymphoma kinase that promotes survival via activation of signaling pathways such as PI3-kinase/AKT [30,31,32,33]; FLT1, which codes for VEGFR1 that plays an important role in angiogenesis and exerts proliferative activity in invasive breast cancer [34] and whose high expression in BC correlates with high-risk of relapse [35]; EPHA4, EPHA7, and EPHB4, which code for three members of the largest family of RTK, the EPH-receptors.