NFE2L2 and benign prostatic hyperplasia: This study determined the role of the inflammatory response, apoptosis, and oxidative stress in the process of BPH, and further verified the relationship of the signal transducer and activator of transcription (STAT3)/nuclear factor-kappa B (NF-κB)- and nuclear factor erythroid 2 related factor 2 (Nrf2)-mediated signaling pathways with BPH induced by HFD.