The following factors might have influenced the heterogeneity: 1) diverse methods of serum parathyroid hormone and calcium detection were used; 2) the criteria of biochemical hypoparathyroidism and hypocalcemia in each study were not completely consistent; 3) the characteristics of the populations varied in the different studies; 4) the confounding factors were different across these studies, and some studies did not adjust these factors; and 5) the quality of each study (NOS score) was not completely consistent. The gene discussed is PTH; the disease is Hypocalcemia.