The seven-fold reduced susceptibility for individuals with APOL1 G2 variant is consistent with the in vitro evidence of lysis of T. b. rhodesiense by plasma containing the APOL1 G2 allele and a study that showed that mice with APOL1 G2 survived longer after infection with T. b. rhodesiense [22,61]. The gene discussed is APOL1; the disease is infection.