Recently, POFUT1 overexpression was shown to have oncogenic activity in CRC through activation of NOTCH1 signaling, and consequently affecting proliferation, invasion and migration.41 Additionally, depletion of POFUT1 or Notch signaling was shown to be associated with converting proliferative cells into goblet cells.32, 42 Indeed, in the present study, low numbers of goblet cells were significantly associated with high‐risk status and high POFUT1 expression in adenomas, indicating that in HRAs POFUT1 and Notch signaling play a role in increased proliferation and decreased differentiation. This evidence concerns the gene NOTCH1 and colorectal carcinoma.