MTOR and cancer: These included pathways known to play a role in or accompany colorectal carcinogenesis like Hedgehog, Notch, KRAS, PI3K/AKT/mTOR or Wnt signaling, proliferation, epithelial‐mesenchymal transition or immune activation.33 This suggests that a lot of processes inherent to cancer are already more active in HRAs compared to LRAs.