Lower amounts of goblet cells were significantly associated with high POFUT1 expression (p = 0.017; Table S11a) and high risk of progression (p = 0.007; Table S11b), implying that also in our study POFUT1 is linked to goblet cell differentiation and indicating its role in early colorectal tumor development. Here, POFUT1 is linked to colorectal neoplasm.