DIS3 and colorectal carcinoma: Chromosome 20 was associated with the largest global expression changes on RNA and protein level with 28 genes (~30%), including HNF4A, TOMM34 and RPRD1B, which were previously described to be gained and overexpressed in CRC cell lines and tissues.27, 28 Gene‐dosage effect was also identified for DIS3, which is located on chromosome 13 and often gained in CRC.27, 29 Other genomic regions with the highest number of perturbed genes considered almost all chromosomes involved in the CAEs.