HNF4A and neoplasm: This included HNF4A, a transcriptional activator of epithelial differentiation35 that is located on chromosomal arm 20q, previously shown to be amplified and activated in the majority of CRCs28 and studied as a prognostic biomarker for this disease.36 An unexpected result was the overexpression of multiple tumor microenvironment‐related genes/proteins in HRAs, including collagens, fibronectin, vimentin, immunoglobulins or calprotectin.