In the adenomas, the CAE‐driven gene‐dosage effect analysis yielded potential drivers of colorectal tumor progression that are already amplified and overexpressed in HRAs—POFUT1, RPRD1B and EIF6. The three genes are located on neighboring cytobands of chromosome arm 20q, which is the most frequently amplified chromosomal arm in CRC.18, 28. The gene discussed is RPRD1B; the disease is colorectal carcinoma.