POFUT1 immunohistochemical staining was predominantly observed in the cytoplasm of epithelial cells, the staining showed gradual increase of POFUT1 expression through different stages of colorectal tumor progression (Figs. 6a and 6b), thereby verifying the molecular profiling data (Fig. 5b). The gene discussed is POFUT1; the disease is colorectal neoplasm.