In addition, further multivariate Cox's regression model analysis was carried out to assess factors affecting OS, which disclosed that ANRIL relative expression (P=0.011, HR 1.763, 95%CI 1.138–2.732), hypertension (P=0.011, HR 92.352, 95%CI 2.782–3065.211), diabetes (P=0.008, HR 92.352, 95%CI 2.782–3065.211), and smoking (P=0.011, HR 50.573, 95%CI 2.501–1022.691) independently predicted poor survival in CAD patients (Supplementary Table S1). This evidence concerns the gene CDKN2B-AS1 and coronary artery disorder.