As described by DuPage, nasal inhalation with 1 × 106 Cre‐expressing lentiviral particles per mouse was carried out to induce lung adenocarcinoma formation in p53(flox/flox); LSL‐Kras‐G12D C57 mice by activating Kras‐G12D expression and P53 deletion and the lung adenocarcinoma tissues were collected to detect the lncRNA expression profiles through microarray analysis containing probes for 58 809 mouse lncRNAs, with the normal mouse lung tissues as controls. Here, TP53 is linked to lung adenocarcinoma.