We noticed an intriguing phenomenon that 16 of the identified conserved lncRNAs located on the chromosome region between the genes for retrotransposon‐like protein 1 and thyroxine 5‐deiodinase, they were all up‐regulated in the mouse lung adenocarcinoma tissues, and expression of 9 lncRNAs was identified to be associated with p53, Kras mutation or hypoxia. This evidence concerns the gene TP53 and lung adenocarcinoma.