In order to identify the possible factors deregulating lncRNAs expression of the mouse lung adenocarcinoma in vitro, primary lung adenocarcinoma cells with K‐rasG12D;p53−/−, namely KP cell in our research, were isolated from the lung adenocarcinoma tissues of p53(flox/flox);LSL‐Kras‐G12D C57 mice induced by nasal inhalation of lentivirus‐Cre. This evidence concerns the gene KRAS and lung adenocarcinoma.