To investigate lncRNAs deregulated in p53‐ and Kras‐mutated lung cancer, the microarrays were used to analyse lncRNA expression profiles in the tissues of mice lung adenocarcinoma tissues with p53 gene deletion and Kras activation induced by nasal inhalation of Cre‐expressing lentivirus in p53(flox/flox);LSL‐Kras‐G12D C57 mice. This evidence concerns the gene TP53 and lung adenocarcinoma.