We further experimentally confirmed that miR‐488 directly binds to the 3′‐UTR of the 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase 3 (PFKFB3) gene, thereby regulating tumor proliferation and glycolysis in PCa. Here, PFKFB3 is linked to neoplasm.