Liu et al. (2018) demonstrated that NCAPG played an oncogenic role in the development of HCC. Shahid et al. (2018) found that CENPF expression was increased in higher risk prostate cancer patients. ENO3 encoded beta-enolase, which was involved in glycolysis and gluconeogenesis, and little information had been reported about the function of ENO3 (Kong et al., 2016). This evidence concerns the gene CENPF and hepatocellular carcinoma.