Binding specificity assay showed that Zapadcine-1 specifically binds to DR5+ tumor cells of Jurkat E6-1, BALL-1 and Reh lymphocyte leukemia cells, as well as NCI-H1975 and MSTO-211H lung cancer cells, but not normal cells of PBMC, BEAS-2B and WRL68 tested (Figure 2A). The gene discussed is TNFRSF10B; the disease is lung cancer.