It is well known that DR4/DR5 are highly expressed in malignant cells, including leukemia, non-small cell lung carcinoma, pancreatic cancer, colon cancer, breast cancer, ovarian cancer and bladder cancer, but less or no expression in the most normal tissues and cells 13, 27, 39, 40. The gene discussed is TNFRSF10B; the disease is familial pancreatic carcinoma.