TNFRSF10B and neoplasm: Since Zapadcine-1 can be effectively internalized into the lysosome and quickly release the toxin MMAD in the cells, therefore to kill DR5 positive tumor cells specifically, including acute T lymphocyte leukemia, acute B lymphocyte leukemia, acute Reh lymphocyte leukemia (non-T and non-B), non-small cell lung cancers.