It is well known that DR4/DR5 are highly expressed in malignant cells, including leukemia, non-small cell lung carcinoma, pancreatic cancer, colon cancer, breast cancer, ovarian cancer and bladder cancer, but less or no expression in the most normal tissues and cells 13, 27, 39, 40. This evidence concerns the gene TNFRSF10A and familial pancreatic carcinoma.