Alzheimer's disease is a chronic neurodegenerative disorder characterized histopathologically by the accumulation of insoluble forms of amyloid-β (Aβ) in plaques and the aggregation of hyperphosphorylated forms of the microtubule-associated protein-tau (p-tau) into neurofibrillary tangles in neurons 1,2. Here, MAPT is linked to Alzheimer disease.