Kaplan-Meier curves revealed that high APLN mRNA expression was significantly associated with worse overall survival in HCC patients from our Guangzhou cohort (n = 80, P < 0.01), TCGA cohort (n = 330, P < 0.01) and GSE76427 cohort (n = 115, P < 0.05) (Figure 1E). The gene discussed is APLN; the disease is hepatocellular carcinoma.