TGFB1 and hepatocellular carcinoma: We first analyzed the correlation of APLN expression with deregulation of ten canonical cancer pathways including cell cycle, Hippo, Myc, Notch, Nrf2, PI3K/Akt, RTK-RAS, TGFβ, p53, and Wnt/β-catenin in TCGA HCC cohort.