HMGB1 and benign prostatic hyperplasia: Furthermore, IHC of 64 paraffin- embedded human PCa tissues and 14 benign prostatic hyperplasia (BPH) or normal prostate samples showed that expression of both HMGB1 (P = 0.008, Table 1) and BRG1 (P = 0.045, Table 1) was dramatically increased in PCa tumors than the corresponding BPH tissues (Figure 7B-C).