It is has been widely reported that PI3K/AKT signaling pathway regulates EMT by promoting the phosphorylation of downstream target proteins (Bad, Caspase9, NF‐κB, GSK‐3β, mTOR, p21Cip1, p27 Kip1, etc.)to further mediates tumor proliferation, invasion and metastases 46-48. This evidence concerns the gene CDKN1A and neoplasm.