Chi‐square analysis demonstrated that expression of HMGB1 and BRG1 was significantly associated with tumor Gleason score/International Society of Urological Pathology (ISUP) Grade Group (PHMGB1 = 0.01 and PBRG1 = 0.006) and clinical stage (PHMGB1 = 0.002 and PBRG1 = 0.045), but not associated with patient's age, T stage, regional lymph nodes, or distant metastasis (Table 2). The gene discussed is SMARCA4; the disease is neoplasm.