HMGB1 and posterior cortical atrophy: Third, deletion of BRG1 partly counteracted the aggressive phenotype mediated by HMGB1. And finally, ectopic expression of BRG1 rescued the attenuation of cellular tumorigenesis and EMT by the knockdown of HMGB1 indicating that BRG1 was required for HMGB1-induced malignant progression in PCa.