In agreement with a previous report that BRCA1 acts as a pivotal suppressor of EZH2 in the PRC2 complex 42, it has been shown recently that EZH2 represses expression of FOXO3, but this regulation only occurs when EZH2 becomes hyperactivated in BRCA1-deficient breast cancer cells 58. The gene discussed is BRCA1; the disease is breast cancer.