Oncomining of previously reported RNA-seq data generated from prostate cancer clinical specimens 46 showed that EZH2 expression negatively correlated with FOXO1 at the mRNA level in a cohort containing both primary and metastasis prostate cancers (r = - 0.55; P = 1e-8) (Figure 2A). Here, FOXO1 is linked to Familial prostate cancer.