TSC2 and low grade glioma: Apart from PPGL, low-grade glioma (LGG) also exhibits a significant negative correlation between miR-21-3p and TSC2 (ρ=-0.18, P=1.3·10-4), as well as a positive one with pS6 levels (in Ser235/236: ρ=0.27, P=1.7·10-8; in Ser240/244: ρ=0.23, P=6.6·10-7) (Figure 4A).