In an experimental model in which mice were transplanted with Lewis lung-cancer and B16F1 melanoma cells, tumor volume was found to be markedly lower in the HRG-knockout group than in wild-type and CD36-knockout groups, and vascular density was also substantially lower in the HRG-knockout group than in CD36-knockout and wild-type groups 97. The gene discussed is HRG; the disease is neoplasm.