ALK and cancer: In addition, zVAD partially rescued brigatinib-induced growth suppression in both ALK-negative (A549, Hep3B and Du145) and ALK-positive (H3122 and H2228) cancer cell lines, whereas 4-PBA compromised brigatinib-induced growth inhibition in ALK-negative cancer cells with no obvious change in ALK-positive cancer cells (Figure S3C).