In this context, the exogenous stabilization of a truncated form of HIF-1α, deleted for its Oxygen Dependent Domain (ODD) 31, 36, namely HIF-1αΔODD (Figure S5), significantly impaired the described TCF4-dependent block of differentiation in normoxic GBM cells, thus allowing their partial Wnt-dependent acquisition of neuronal traits (Figure 4A-C). The gene discussed is TCF4; the disease is glioblastoma.