Moreover, by performing a multi-correlation analysis, we intriguingly found that: i) samples harboring a relatively low expression of HIF-1α and a low/absent staining for TCF1 showed a restricted βIII-tubulin expression; ii) low HIF-1α, but high positivity for TCF1 were found in samples characterized by an intermediate expression of βIII-tubulin; iii) glioma samples displaying high expression levels of both HIF-1α and TCF1 were also endowed with the most intense βIII-tubulin staining (Figure 6A-C). Here, TCF7 is linked to central nervous system cancer.