BRCA1 and ovarian cancer: Further, resistance to taxanes, such as cabazitaxel is reported as a multi-drug resistance accompanied by elevated class III β-tubulin RNA (TUBB3) expression and altered microtubule dynamicity, as well as decreased expression of the cell cycle regulator BRCA1 and the induction of epithelial-to-mesenchymal transition (EMT) in breast and ovarian cancer models 23.