Theseobservations together with the previous studies thatreported overexpression of PAPOLG (neo-PAP) inmany cancer types(Topalian et al., 2001)suggest that itsoverexpression may have critical consequences duringthe development of FL or tFL through elevated transcriptpolyadenylation that may result in a more aggressive tumorphenotype as observed for PAP, another poly A polymerasegene, overexpressed in breast cancer(Scorilas et al., 2000). The gene discussed is PAPOLG; the disease is cancer.