Histological features of tumours surgically resected after trabectedin showed a major pathological response, with cellular depletion, disappearance of the capillary network, deposition of sclerohyaline material and adipocytic differentiation.4 One possible explanation for this peculiar response was related to trabectedin’s ability to inactivate the FUS/CHP chimeric protein, thus allowing reactivation of the adipogenic pathway.6 Here, FUS is linked to neoplasm.