p53 cluster positivity was also significantly associated with shorter time to BCR (HR 2.0, 95% CI 1.5–2.7; p < 0.0001, Fig. 2a), metastatic relapse (HR 5.1, 95% CI 2.3–11.5; p < 0.0001, Fig. 2b) and PC-specific mortality (HR 21.8, 95% CI 2.9–162; p = 0.003, Fig. 2c). The gene discussed is BCR; the disease is pachyonychia congenita.