TP53 and pachyonychia congenita: In two studies of radiation and androgen deprivation therapy for locally advanced PC, evidence of p53 alteration based on immunohistochemistry was associated with MR and PC-specific death.8,9 The relationship between p53 and androgen deprivation therapy was conflicting, suggesting a lack of benefit from androgen deprivation therapy in the p53 mutated group in one study, while the other suggested androgen deprivation therapy was imperative in this patient subset.