We demonstrated that Retinal Degeneration Protein 3 (RD3), which is constitutively expressed in human tissues28, has a regulatory role in NB evolution, and RD3 loss (i) contributes to the altered metastatic state of the NB cells in vitro and (ii) pathogenesis of disease progression in vivo, and (iii) is associated with advanced disease stage and poor clinical outcomes29. Here, RD3 is linked to neuroblastoma.