Utilizing the NM-PX and PD mouse models and the MSDACs, we investigated the association of (a) transcriptional and/or (b) translational loss of RD3 in disease progression, and the driving role of RD3 loss in the pathogenesis of MYCN-na NB progression, (c) tumor cell migration, (d) invasive potential, and (e) tumorosphere formation. The gene discussed is MYCN; the disease is neoplasm.