In fact, the 2016 European Society of Cardiology /European Atherosclerosis Society (ESC/EAS) Guidelines for the management of dyslipidemias advocates that non-high-density lipoprotein cholesterol (non-HDL-c) and Apolipoprotein B (ApoB) should be evaluated and considered secondary targets for lipid control3. This evidence concerns the gene APOB and metabolic syndrome.