As the LRP1 precursor (~600 kDa) is cleaved by furin in the TGN to generate a 515-kDa α chain (LRP1-α-chain) and an 85-kDa membrane-anchored cytoplasmic β chain (LRP1-β-chain), we determined the amounts of α-chain and β-chain of LRP1 proteins after cerebral ischemia. This evidence concerns the gene FURIN and brain ischemia.