In summary, we show for the first time in a model of both paclitaxel- and oxaliplatin-related CIPN that the activation of IL-8 signalling is involved in the development of peripheral neuropathies, and that interfering with this signal using the novel compound DF2726A may be a useful strategy to alleviate chemotherapy-induced neurotoxicity. The gene discussed is CXCL8; the disease is peripheral neuropathy.