TNF and lobular neoplasia: As depicted in Table 3, GA genotype and minor allele (A) of TNF-α (G-238A) polymorphism was more frequent in patients with lupus nephritis (LN+) compared to those patients without renal involvement (LN−) (GA: P = 0.002, OR = 2.89;A: P < 0.001, OR = 2.92).