SLC16A1 and colorectal carcinoma: Interestingly, there was no synergistic effect on CRC suppression and LC3-II conversion of OSI with AZD3965 (a MCT1 inhibitor that blocks its lactate transporting function) (Supplementary Fig. 7A, C), implying that the mechanism of MCT1-mediated autophagy might be independent of the monocarboxylate-transporting function of MCT1.