The lower efficiency of hiPOD permselectivity could possibly stem from to the lower expression of laminin or collagen-binding components like α3, α1, and β1 integrin chains and CD151 (which associates with cell-matrix complexes like integrins), integrin chains β3, α5, αV that instead mediate fibronectin binding and are activated in progressive CKD, as shown in our previous work25. This evidence concerns the gene FN1 and chronic kidney disease.