To investigate the possible mechanisms underlying DcR3 expression in HCC, we treated MHCC97L and SMMC7721 HCC cell lines (in which DcR3 expression was relatively lower than in other HCC cell lines, as shown in Supporting Fig. S1) with recombinant human TGFβ3 (rhTGFβ3). Here, TNFRSF6B is linked to hepatocellular carcinoma.