To determine which of these may be responsible for the death of AML cells after mitocan exposure, we assayed cell viability after treatment with MTX, DOX, and CCCP in the presence of caspase inhibitors (z-VAD-fmk for all caspases and VX-765, for caspase-1) or an autophagic inhibitor (3-methyladenine, 3-MA)25–27. Here, CASP1 is linked to acute myeloid leukemia.