CCND1 and hepatocellular carcinoma: In conclusion, our results demonstrate that the combination of lonafarnib and sorafenib induced the formation of autophagosomes and suppressed cell viability, and a decrease in cyclin D1 by autophagic flux and subsequent cell cycle arrest were involved in the mechanism mediating the effect of lonafarnib and sorafenib co-treatment in HCC cells Figure 8.