For example, Liu et al. suggested that COL1A1 promoted metastasis of breast cancer [39]; Zhang et al. found that COL1A1 facilitated metastasis by regulating the WNT/PCP pathway in colorectal cancer [40]; Yu et al. confirmed that COL1A2 inhibited colorectal cancer cell proliferation, migration and invasion [41]. This evidence concerns the gene COL1A1 and colorectal cancer.