MAPK8 and diffuse large B-cell lymphoma: The results of MAPK phosphorylation showed a similar trend to the phosphorylation observed in DLBCL and normal/activated B cells, indicating a significant decrease in the P-ERK:ERK ratio and increase in the P-JNK:JNK ratio in RasGRP4-knockdown SUDHL-4 cells (Fig. 4d–f).