The results showed that the RasGRP4 expression was significantly higher in DLBCL patients with a largest lesion diameter of ≥10 cm compared to those with the largest lesion diameter of < 10 cm (P = 0.0004, Fig. 6a, staining data in Additional file 2: Figure S2). This evidence concerns the gene RASGRP4 and diffuse large B-cell lymphoma.