Interestingly, it has been shown that in C2C12 mouse myotubes ADMA is able to induce insulin resistance by reducing expression of both the insulin receptor substrate-1 and GLUT-4 glucose transporter, and increasing expression protein tyrosine phosphatase 1B (PTP1B), thus resulting in impaired insulin signaling, and reduced glucose uptake [33]. Here, IRS1 is linked to Insulin resistance.