In multivariable analysis, IgG log10 FC was associated with malaria protection for EXP1 (OR = 0.6 [0.38; 0.91], p = 0.02), MSP2 Dd2 (OR = 0.54 [0.32; 0.87], p = 0.02), and MSP2 CH150 (OR = 0.58 [0.37; 0.88], p = 0.01, also for IgM). The gene discussed is CD40LG; the disease is malaria.