CTLA4 and melanoma: In 2011 the first ICI, a monoclonal antibody targeting cytotoxic T lymphocyte-associated protein 4 (anti-CTLA-4 or αCTLA-4), was approved for use in advanced melanoma and followed in 2014 by another ICI targeting programmed cell death protein 1 (anti-PD-1 or αPD-1) [2–5].