One of them was adiponectin (ADIPOQ), besides being verified as a prognostic molecule in DN prognosis studies [29–31], it was observed increased in the serum of DN patients, protected the kidney by reducing inflammatory response and ameliorating glomerular hypertrophy and albuminuria, as an anti-inflammatory adipokine and insulin sensitizer mainly secreted by adipocytes [32]. This evidence concerns the gene INS and liver dysplastic nodule.