ACP3 and central precocious puberty: Hierarchical clustering performed separately for each histologically defined group of CPPs (Additional file 2: Figure S6A) and aCPPs (Additional file 2: Figure S6B) from the replication cohort is able to clearly distinguish a subset within each of the CPP and aCPP groups based on their DNAm profiles, although histologically they were all classified as either CPP or aCPP.