On the other hand, the NEfERT-T trial (NCT00915018) that compared the efficacy of neratinib + paclitaxel versus trastuzumab + paclitaxel as the first-line therapy in women with previously untreated recurrent or metastatic HER2+ve breast cancer showed lower incidence of CNS recurrence in the neratinib-treated compared to the trastuzumab-treated group (8.3% versus 17.3%, respectively) and delayed time to CNS metastases [24] indicating that patients at risk of brain metastasis may benefit from earlier intervention. Here, ERBB2 is linked to breast carcinoma.