SETD2 and overgrowth syndrome: NSD1 catalyzes the addition of either monomethyl (H3K36me) or dimethyl groups (H3K36me2) and indirectly regulates the levels of trimethylation (H3K36me3) by altering the availability of the monomethyl and dimethyl substrates for the trimethylation enzymes (SETD2 in humans, whose mutations cause a “Sotos-like” overgrowth syndrome) [52, 53].