It has been reported that MMP2 and MMP9 were closely related to cells migration in various cancers including bladder cancer, osteosarcoma, hepatocellular carcinoma, thyroid cancer, gastric adenocarcinoma [17–20], which are mediated by many signal pathways including MAPK/P38 signaling [21, 22], PI3K/AKT signaling [23, 24], Wnt/Frizzled signaling [25] accompanied by epithelial to mesenchymal transition (EMT), drug resistance [26, 27] and tumor progression. This evidence concerns the gene MMP2 and cancer.