Moreover, as the observed immune processes were blunted by the anti TNFSF10 treatment, it was of interest that the expression of IL-10 was increased in 3xTg-AD mice treated with the anti TNFSF10 antibody, suggesting a setting into motion of the anti-inflammatory response in the brain of the 3xTg-AD animals, while FoxP3 expression was downregulated (Fig. 4c; white arrows). This evidence concerns the gene TNFSF10 and Alzheimer disease.