TNFSF10 and Alzheimer disease: With such rationale, and with the aim to better highlight a hypothetical prominent role of the peripheral immune system in AD, we here investigate whether immunoneutralization of TNFSF10 is related to a re-balance of both the central and the peripheral immune response, and whether this could correlate with decreased Aβ burden in the CNS, consistently with the previously demonstrated improvement of the cognitive outcome in 3xTg-AD mice [19].