TNFSF10 and Alzheimer disease: In this line, we have previously shown that TNFSF10 is substantially expressed in both the human AD brain [50], as well as in the hippocampus of 3xTg-AD mice [19], and that its immunoneutralization by means of a monoclonal antibody against TNFS10, is associated with an almost complete recovery of cognitive capacities, along with blunted expression of inflammatory mediators in the brain [19].