TNFSF10 and Alzheimer disease: Immunohistochemical and Western blot analysis performed on spleen samples revealed specific immunoreactivity for amyloid beta 1–42 in AD vehicle (Fig. 2(a, C, black arrows; b)) and AD anti-TNFSF10 (Fig. 2(a, D, black arrows; b)) spleen sections, while spleens from WT animals (untreated; treated with anti-TNFS10) did not show any specific immunoreactivity for amyloid beta 1–42 (Fig. 2(a, A and B, respectively; b)).