Given our results showing that sFGL2 blockage leads to DC activation in hepatoma, we then investigated the mechanism associated with sFGL2 abolition of DC activation by culturing immature BMDCs with 4 μg/mL recombinant murine FGL2 for 16 h, followed by stimulation with LPS for 12 h (Fig. 5a). Here, FGL2 is linked to hepatocellular carcinoma.