Current time updated CD4 count < 500 cells/mm3 (p < 0.0001), virologic failure on ART (aHR: 3.05 (95% CI: 2.094, 4.454), p < 0.0001) and receipt of ART without IPT (aHR: 8.24 (95% CI: 3.358, 20.204), p < 0.0001) were associated with higher risk of incident TB on univariate and multivariate Cox regression analysis (Table 4). This evidence concerns the gene CD4 and tuberculosis.