Compared to patients with current time updated CD4 count > 500 cells/mm3, patients with current CD4 count ≤200, 201–350, and 351–500 cells/mm3 were six times (aHR: 6.62 (95% CI: 3.678, 11.915), p < 0.0001), three times (aHR: 3.22 (95% CI: 1.808, 5.746), p < 0.0001) and two times (aHR: 2.05 (95% CI: 1.083, 3.888), p = 0.027) more likely to develop incident TB respectively (Fig. 2). The gene discussed is CD4; the disease is tuberculosis.