Strikingly among 7 HSNs, N8 (adjacent to a stage 4 poorly differentiated tumor with LN metastasis/R0) had the highest expression of MMP2, MMP14, COL6A1, COL6A2, COL1A2, COL1A1, CXCR1 and CXCR2 across all 79 normal samples while N58 (adjacent to a stage 3 well differentiated tumor with LN metastasis/R2) had the highest expression MYC and CDK4 across all 79 normal samples. This evidence concerns the gene CDK4 and neoplasm.