All 3 oncogenes in 50 CRCs, except for MYC in one tumor and CDK4 in three tumors, were upregulated (Additional file 1: Figure S5a) and 3 normal colonic physiological genes were downregulated, except for CD177 in one tumor, AQP8 in two tumors and GPX3 in three tumors. This evidence concerns the gene AQP8 and neoplasm.