Although various tools like Genorm, NormFinder, or BestKeeper have each defined a suitable set of classical reference genes for specific qPCR studies, recent cancer studies found that normalization of gene expression levels using classical ACTB and GAPDH introduced artifacts in qPCR results because of non-uniformity of reference gene expression in mouse fibroblasts [6] and in human cancer lines [7]. This evidence concerns the gene GAPDH and cancer.