Pathogenic variants in the SCN2A gene that produce loss-of-function of the protein lead to ASD/ID and increased channel activity that lead to epileptic encephalopathy early infantile 11 (EEIE11) and benign familial neonatal-infantile seizures (BFIS) [52]. Here, SCN2A is linked to Benign familial neonatal-infantile seizures.