Given that our results show that TNS4 appears to serve as a converged downstream effector of both EGFR and ERK signaling pathways, it is tempting to speculate that effective downregulation of TNS4 by the drugs targeting these signaling acts as a crucial determinant leading to antitumor effect in KRAS mutation-harboring CRC. This evidence concerns the gene EGFR and colorectal carcinoma.