KRAS and malignant colon neoplasm: Further analysis of these selected genes with CCLE database identified that TNS4, a member of the Tensin protein family member involved in key cellular process including cell adhesion, migration and proliferation, was of great interest because it was specifically expressed in a colon cancer cell line (Figure 1C) as well as up-regulated in KRAS mutated cell lines compared to wild type cell lines (Figure 1D) [32,33].