TNS4 and cancer: To avoid this issue, we focused on TNS4, a member of the Tensin protein family member, involved in a key cellular process including cell adhesion, migration, and proliferation, for further functional studies to test our hypotheses because TNS4 was found to be upregulated in various types of cancer and its expression is significantly correlated with KRAS mutation status in CRC cell lines based on our analysis [30,32,34,37,38,39,40].