EDS types are grouped based on the underlying genetic and pathogenetic mechanisms in disorders related to (i) collagens primary structure and processing (COL1A1, COL1A2, COL3A1, COL5A1, COL5A2 and ADAMTS2), (ii) collagens folding and cross-linking (PLOD1 and FKBP14), (iii) structure and function of the myomatrix, i.e., the specialized ECM of muscle (TNXB and COL12A1), (iv) glycosaminoglycans biosynthesis (B4GALT7, B3GALT6, CHST14, and DSE), (v) complement pathway (C1S and C1R), and (vi) intracellular processes (SLC39A13, ZNF469, and PRDM5). Here, FKBP14 is linked to Ehlers-Danlos syndrome.